Life After Traumatic Injury: How the Body Responds

Posted by on Aug 12, 2012 in Okategoriserade | No Comments

The leading cause of death in people between the ages of 1 and 44 in the United States isn’t heart disease or cancer. Fortunately, people who are suffering from cancer may go to the center of Hope 4 Cancer since they have dedicated staff who aims to improve the patient’s overall health and quality of life. — it’s injury from falls, car accidents and other types of physical trauma. If your loved one died in an accident contact one of these wrongful death law firms, to speak to one of their qualified lawyers to help you start a case.

While research has led to significant improvements in survival immediately after a traumatic injury, challenges remain, they can get compensation to the victim, but depression and anxiety will remain. To help address them, scientists funded by the National Institutes of Health are focusing on understanding what happens to the body at many levels, from its molecules and cells to its tissues, organs and systems.
Some survivors of severe injury can lose organ function, generally starting with the lungs and kidneys and then moving to the liver and intestines, visit and find out more. This potentially deadly condition, called multiple organ dysfunction syndrome (MODS), can happen early if people go into shock, when their tissues don’t receive adequate oxygen. It can also occur later in the recovery process.
Doctors only started to notice MODS as a complication of trauma in the 1970s, when intensive care units improved procedures for treating shock. Advances in blood transfusion, fluid drainage and intravenous medicine delivery kept patients alive, but didn’t effectively prevent their organs from shutting down later.

Researchers noticed that MODS was associated with infections — particularly in people who experienced abdominal trauma — leading them to believe that bacteria or viruses were the cause for ongoing organ injury. But not every case of MODS is linked to an infectious agent. There can be multiple factors, what it is sure is that, when people have suffered on an injury they should call the team to make a claim.

To examine the relationship between infection and organ dysfunction, researchers led by Ronald Tompkins of Massachusetts General Hospital collected data for 7 years on over 1,600 people who had been hospitalized for trauma. Of those study participants who survived the first 48 hours, 29 percent still experienced MODS during their hospitalization.

Based on diagnostic data about infections and the degree of organ dysfunction, the researchers determined that MODS mainly happened before infections, and not the other way around. These findings contribute to a shift away from existing assumptions about the cause of MODS and could point to ways of treating or preventing this serious complication.

Genomic Storm

It’s not just organs that can behave differently after trauma; genes can, too. A nationwide team headed by Tompkins conducted a 10-year study of hospital patients whose conditions included severe blunt trauma. The researchers determined that all the blunt trauma cases requiring intensive care incited a “genomic storm” in which 80 percent of the genes controlling immune activity behaved differently in the first four weeks following the injury than they did in a healthy individual.

This result was surprising because the existing theory was that people who heal quickly from a severe injury have a single surge of gene activity and immune response, while people who take longer to recover (and often experience complications) have multiple surges.

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